Noam presented his final PhD seminar entitled "Single-Molecule Protein Sensing for Early AMD Diagnosis”
In his seminar, he talked about the use of single-molecule sensing technology for early detection of age-related macular degeneration (AMD), a leading cause of vision loss in older adults. Unlike traditional methods that detect physical damage, this approach analyzes molecular biomarkers like VEGF and Clusterin with high precision. Single-molecule techniques, such as nanopore-based sensors or dynamic sensing using nanoparticles, allow real-time tracking of individual protein interactions, enabling ultrasensitive detection at subfemtomolar levels. These methods improve diagnostic accuracy by identifying molecular changes before significant vision loss occurs, paving the way for earlier intervention and personalized treatments. This innovation could transform AMD management, reducing its socioeconomic impact and enhancing patient outcomes.
Welcome to Meller lab, Ali Kayyal!
Ali Kayyal, new MSc student joined our Lab.
Ali’s research will focus on developing an innovative deep-learning approach for protein classification, using data derived from protein sensing and tracking experiments. This work aims to improve classification accuracy and reveal subtle patterns within protein structures and dynamics, advancing proteomic analysis.
Welcome to our team Ali and best of luck!
Neeraj Soni talk at Indian Institute of Technology Mandi
Neeraj Soni, PhD student in Meller lab visited IIT Mandi and presented his PhD work , in which he talked about the feasibility of whole protein identification and sequencing through sub 5nm solid state nanopore.
Neeraj extensively discussed the biophysical characteristics associated with the single-file translocation of whole proteins, underscoring its importance in contrast to traditional methods. Additionally, he delved into inventive strategies for regulating the dynamics of the translocating molecule as it passes through nanopores.
The lab perspective paper on the emerging field of single-molecule protein identification is out on Nature Methods
Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biological discovery and open new avenues for ultrasensitive disease diagnostics.
Shilo Ohayon presents a talk at the: HealthIL - BME Satellite Event: Engineering the Future of Healthcare
Shilo Ohayon presented the lab research and advancement in single-molecule protein identification and quantification technologies. The 10 min talk was aimed at the general audience and reviewed the latest developments in single-molecule sensing, optical sensing using nanotechnologies such as nanopores and submicron channels.
The talk briefly explained the foundations these technologies are based upon and the importance of this technology have on digital health.
In the future, we believe our technology could assist fast and accurate diagnostic in the community and better monitoring of patients.
Prof. Meller delivered the Joan van der Waals colloquium in Leiden University
On October 26, 2018, Prof. Meller delivered the Joan van der Waals colloquium in the Department of Physics, Leiden University, the Netherlands. The broadly accessed colloquium was entitled “Nanopore bio-sensing: past, present and future” and covered over 20 years of nanopore research towards DNA sequencing as well as recent developments leading to
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