Meller lab team new paper in Advanced Materials journal

Full-Length Single Protein Molecules Tracking and Counting in thin Silicon Channels

In this paper, we introduce a single-molecule method for parallel protein separation and tracking, yielding multi-dimensional and are electrophoretically separated by their mass/charge in custom-designed thin silicon channel with subwavelength height. This approach allows us to analyse thousands of individual proteins within a few minutes by tracking their motion during the migration. We demonstrate the power of the method by quantifying a cytokine panel for host-response discrimination between viral and bacterial infections.

Check the onilne paper

Simulation of single-protein nanopore sensing shows feasibility for whole-proteome identification

Our simulations study show feasibility of whole proteome nanopore sensing. Shilo, Arik and Maisa’s paper final version is published in the Open Access journal PloS Computational Biology Congratulations!

Congratulations to Nitinun for the publication of her Chem Society Review paper

Proteins are the structural elements and machinery of cells responsible for a functioning biological architecture and homeostasis. Advances in nanotechnology are catalyzing key breakthroughs in many areas, including the analysis and study of proteins at the single-molecule level. Nanopore sensing is at the forefront of this revolution. This tutorial review, published on October 17, 2018, provides readers a guidebook and reference for detecting and characterizing proteins at the single-molecule level using nanopores. Specifically, the review describes the key materials, nanoscale features, and design requirements of nanopores. It also discusses general design requirements as well as details on the analysis of protein translocation. Finally, the article provides the background necessary to understand current research trends and to encourage the identification of new biomedical applications for protein sensing using nanopores.