Noam presented his final PhD seminar entitled "Single-Molecule Protein Sensing for Early AMD Diagnosis”
In his seminar, he talked about the use of single-molecule sensing technology for early detection of age-related macular degeneration (AMD), a leading cause of vision loss in older adults. Unlike traditional methods that detect physical damage, this approach analyzes molecular biomarkers like VEGF and Clusterin with high precision. Single-molecule techniques, such as nanopore-based sensors or dynamic sensing using nanoparticles, allow real-time tracking of individual protein interactions, enabling ultrasensitive detection at subfemtomolar levels. These methods improve diagnostic accuracy by identifying molecular changes before significant vision loss occurs, paving the way for earlier intervention and personalized treatments. This innovation could transform AMD management, reducing its socioeconomic impact and enhancing patient outcomes.
Welcome to Meller lab, Ali Kayyal!
Ali Kayyal, new MSc student joined our Lab.
Ali’s research will focus on developing an innovative deep-learning approach for protein classification, using data derived from protein sensing and tracking experiments. This work aims to improve classification accuracy and reveal subtle patterns within protein structures and dynamics, advancing proteomic analysis.
Welcome to our team Ali and best of luck!
Celebrating Rosh Hashanah in Meller lab
As we welcome the Jewish New Year, Rosh Hashanah, our lab takes a moment to reflect on the past year and embrace the opportunities ahead.
We raised a toast to celebrate the new year together.
we wish you a sweet and fulfilling new year! Shana Tova!
Prof. Meller delivers the Inaugural Speech at FARC 2024 conference in IIT Mandi, India.
Professor Meller recently attended the FARC 2024 conference (International Conference on Fundamental and Advanced Research in Chemistry) held at the Indian Institute of Technology Mandi, H.P., India. At this esteemed event, Prof. Meller was honored with the inaugural speech, marking a significant recognition of his groundbreaking contributions to the field of chemistry.
The FARC 2024 conference gathered leading researchers, scholars, and industry experts from around the globe to discuss the latest advancements and innovations in chemistry.
for more information about the FARC 2024 conference click here.
Meller lab team new paper in Advanced Materials journal
Full-Length Single Protein Molecules Tracking and Counting in thin Silicon Channels
In this paper, we introduce a single-molecule method for parallel protein separation and tracking, yielding multi-dimensional and are electrophoretically separated by their mass/charge in custom-designed thin silicon channel with subwavelength height. This approach allows us to analyse thousands of individual proteins within a few minutes by tracking their motion during the migration. We demonstrate the power of the method by quantifying a cytokine panel for host-response discrimination between viral and bacterial infections.
Check out the recent highlight of Our Nano letters paper featured in Advance in Engineering
Surfing the Nano Wave: Dramatic Leap in DNA Sensing with Surfactant-Coated Nanopores
The online platform of Advances in Engineering has showcased our recent Nano Letters article, titled "Over 30-Fold Enhancement in DNA Translocation Dynamics through Nanoscale Pores Coated with an Anionic Surfactant''.
Read the highlight here
Read the paper here