Neeraj Soni won the best presentation award at Single Molecule Biophysics Conference, France 2022

Neeraj Soni, a Ph.D. student in our group, won the best presentation award at Single Molecule Biophysics Conference, France 2022.

His presentation title : "Denatured protein translocations using sub 5 nm Solid-state nanopores”.

Proteins are the main constituents of all biological cells and are responsible for most of the cellular functions. Many of the current disease-specific biomarkers are proteins or modified versions of proteins hence creating a need for sensitive yet simple methods for protein identifications in clinical diagnostics applications. Herein, we developed a highly sensitive approach for identifying wide range lengths SDS denatured protein complexes. Given the simplicity and eradication of the tailor-made necessities, this assay holds the full potential to sequence the protein at a single-molecule level in the future.

Way to go Neeraj!

Congratulations to Nitinun for the publication of her Chem Society Review paper

Proteins are the structural elements and machinery of cells responsible for a functioning biological architecture and homeostasis. Advances in nanotechnology are catalyzing key breakthroughs in many areas, including the analysis and study of proteins at the single-molecule level. Nanopore sensing is at the forefront of this revolution. This tutorial review, published on October 17, 2018, provides readers a guidebook and reference for detecting and characterizing proteins at the single-molecule level using nanopores. Specifically, the review describes the key materials, nanoscale features, and design requirements of nanopores. It also discusses general design requirements as well as details on the analysis of protein translocation. Finally, the article provides the background necessary to understand current research trends and to encourage the identification of new biomedical applications for protein sensing using nanopores.