Meller lab team new paper in Advanced Materials journal

Full-Length Single Protein Molecules Tracking and Counting in thin Silicon Channels

In this paper, we introduce a single-molecule method for parallel protein separation and tracking, yielding multi-dimensional and are electrophoretically separated by their mass/charge in custom-designed thin silicon channel with subwavelength height. This approach allows us to analyse thousands of individual proteins within a few minutes by tracking their motion during the migration. We demonstrate the power of the method by quantifying a cytokine panel for host-response discrimination between viral and bacterial infections.

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Congratulations to Eran on his ACS Nano paper reporting fast and deterministic nanopore drilling

In a latest publication, we develop a custom algorithm (called NLDA) and software to deliver a deterministic fashion of sub-nanopore laser drilling. We provide a full recipe to obtain the fabricated pores with a preset diameter (error) in less than two minutes. The in situ technique enables instant protein sensing following the nanopore formation. Our findings bring insights into the laser-drilled nanopore 3D shape, which contributes to the sensor’s biomolecule capture capabilities.

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Congratulations to Nitinun for the publication of her Chem Society Review paper

Proteins are the structural elements and machinery of cells responsible for a functioning biological architecture and homeostasis. Advances in nanotechnology are catalyzing key breakthroughs in many areas, including the analysis and study of proteins at the single-molecule level. Nanopore sensing is at the forefront of this revolution. This tutorial review, published on October 17, 2018, provides readers a guidebook and reference for detecting and characterizing proteins at the single-molecule level using nanopores. Specifically, the review describes the key materials, nanoscale features, and design requirements of nanopores. It also discusses general design requirements as well as details on the analysis of protein translocation. Finally, the article provides the background necessary to understand current research trends and to encourage the identification of new biomedical applications for protein sensing using nanopores.