Surfing the Nano Wave: Dramatic Leap in DNA Sensing with Surfactant-Coated Nanopores
The online platform of Advances in Engineering has showcased our recent Nano Letters article, titled "Over 30-Fold Enhancement in DNA Translocation Dynamics through Nanoscale Pores Coated with an Anionic Surfactant''.
Read the highlight here
Read the paper here
Nanopore identification of single nucleotide mutations in circulating tumor DNA by multiplexed ligation:
In this paper we introduce a new and transformative technology, based on sophisticated solid state electro-optical Nanopore biosensors, to enable a highly practical method for DNA mutation identification and quantification.
This proof of principle study demonstrates how coupling our technology together with Ligation based SNV detection could potentially be used for clinical diagnosis of cancer biomarkers, especially relevant for early diagnosis of the disease. By permitting high degree of multiplexing of single nucleotide mutation samples and extremely high accuracy, our approach could offer a rapid and low-cost technique for ctDNA analysis that completely circumvents PCR amplification and library preparation.
The Nano.IL conference is the premier international annual meeting in Nanosciences and Nanotechnology in Israel. On October 11, 2018, our Ph.D. student, Tal Gilboa, won “Best Poster Presentation”, among hundreds of participants. In the poster, she presented her work on Single Molecule Electro-optical Sensing in Solid-state Nanopores.
