Meller lab team new paper in Advanced Materials journal

Full-Length Single Protein Molecules Tracking and Counting in thin Silicon Channels

In this paper, we introduce a single-molecule method for parallel protein separation and tracking, yielding multi-dimensional and are electrophoretically separated by their mass/charge in custom-designed thin silicon channel with subwavelength height. This approach allows us to analyse thousands of individual proteins within a few minutes by tracking their motion during the migration. We demonstrate the power of the method by quantifying a cytokine panel for host-response discrimination between viral and bacterial infections.

Check the onilne paper

Neeraj Soni talk at Indian Institute of Technology Mandi

Neeraj Soni, PhD student in Meller lab visited IIT Mandi and presented his PhD work , in which he talked about the feasibility of whole protein identification and sequencing through sub 5nm solid state nanopore.

Neeraj extensively discussed the biophysical characteristics associated with the single-file translocation of whole proteins, underscoring its importance in contrast to traditional methods. Additionally, he delved into inventive strategies for regulating the dynamics of the translocating molecule as it passes through nanopores.

Our lab members represented us in SMPS3 conference in Delft, the Netherlands.

Dr. Yulia Marom, Dr. Navneet Verma Chandra, Neeraj, Liran, Shilo, Noam, and Prof. Meller presented our research in single molecule sequencing. The group presented five different posters, each one on a different topic.

Meller lab won the 2022 MOST Sweden-Israel award.

Prof. Meller is among the recipients of this year’s awards - The MOST Sweden-Israel award with his colleagues at the Royal Institute of Technology, to develop novel plasmonic nanopore sensors for clinical bio molecular markers.

Prof. Meller won The Diane Sherman Prize for Medical Innovation for a Better World

Prof. Meller was awarded the 2021-2022 Academic Excellence Award :

The Diane Sherman Prize for Medical Innovation for a Better World.

Neeraj Soni won the best presentation award at Single Molecule Biophysics Conference, France 2022

Neeraj Soni, a Ph.D. student in our group, won the best presentation award at Single Molecule Biophysics Conference, France 2022.

His presentation title : "Denatured protein translocations using sub 5 nm Solid-state nanopores”.

Proteins are the main constituents of all biological cells and are responsible for most of the cellular functions. Many of the current disease-specific biomarkers are proteins or modified versions of proteins hence creating a need for sensitive yet simple methods for protein identifications in clinical diagnostics applications. Herein, we developed a highly sensitive approach for identifying wide range lengths SDS denatured protein complexes. Given the simplicity and eradication of the tailor-made necessities, this assay holds the full potential to sequence the protein at a single-molecule level in the future.

Way to go Neeraj!