Check our new paper in ACS Nano Journal about amplification-free mitochondrial DNA quantification
In our latest research, we introduce a solid-state nanopore method for label-free, amplification-free detection of mitochondrial DNA (mtDNA), a key biomarker for disease. Using machine learning and exonuclease digestion, we achieve high accuracy in distinguishing mtDNA from genomic DNA in biological samples. This approach offers picomolar sensitivity with minimal preparation, making it ideal for clinical diagnostics.
Titanium dioxide Nanopores for low background sensing
In a recent publication (ACS Nano, November 2018, DOI: 10.1021/acsnano.8b07055) we showed that thin titanium dioxide membranes produce negligible photoluminescence background as compared to silicon nitride membranes of same thickness. This discovery permits electrooptical sensing in nanopores with much improved signal-to-background ratio, allowing us to use it for sensing and discrimination among labelled DNA strands as well as polypeptides for the first time.