The triple N team (Neeraj, Navneet and Noam.T) has made a leap with the new ACS Nano Letters paper, making this Prof. Meller’s hundredth paper: Over 30-Fold Enhancement in DNA Translocation Dynamics through Nanoscale Pores Coated with an Anionic Surfactant.
In this work, we modulated the surface charges of the ssNP by a negatively charged surfactant SDS. This alteration in the nanopore surface is able to regulate the ElectroOsmotic Flow (EOF) inside the nanopore. The EOF dramatically improves the performance of the NP by >30-fold, slowing down DNA translocation speed without degrading NP noise. In addition, surfactant-coated ssNPs can be employed to sense short DNA fragments at high voltage bias accurately. In addition, by visualizing the electrically neutral fluorophores, we are able to shed light on the EOF processes occurring inside and in close proximity to the planar ssNPs.
Read the full paper here
